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Index > Protein center > Col18a1(Gene name) > Mouse
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  • Col18a1 (Gene name),
  • Collagen alpha-1(XVIII) chain (Protein name ),  COIA1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Col18a1;
    Protein name:
    Collagen alpha-1(XVIII) chain;
    Alternative:
    Endostatin;
    Organism:
    Col18a1 (Mus musculus). 
    General Annotation
    Sub Unit:
    Function:
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    1774
    Sequence:
    50:
    MAPDPSRRLC | LLLLLLLSCR | LVPASADGNS | LSPLNPLVWL | WPPKTSDSLE | 
    100:
    GPVSKPQNSS | PVQSTENPTT | HVVPQDGLTE | QQTTPASSEL | PPEEEEEEDQ | 
    150:
    KAGQGGSPAT | PAVPIPLVAP | AASPDMKEEN | VAGVGAKILN | VAQGIRSFVQ | 
    200:
    LWDEDSTIGH | SAGTEVPDSS | IPTVLPSPAE | LSSAPQGSKT | TLWLSSAIPS | 
    250:
    SPDAQTTEAG | TLAVPTQLPP | FQSNLQAPLG | RPSAPPDFPG | RAFLSSSTDQ | 
    300:
    GSSWGNQEPP | RQPQHLEGKG | FLPMTARSSQ | QHRHSDVHSD | IHGHVPLLPL | 
    350:
    VTGPLVTASL | SVHGLLSVPS | SDPSGQLSQV | AALPGFPGTW | VSHVAPSSGT | 
    400:
    GLSNDSALAG | NGSLTSTSRC | LPLPPTLTLC | SRLGIGHFWL | PNHLHHTDSV | 
    450:
    EVEATVQAWG | RFLHTNCHPF | LAWFFCLLLA | PSCGPGPPPP | LPPCRQFCEA | 
    500:
    LEDECWNYLA | GDRLPVVCAS | LPSQEDGYCV | FIGPAAENVA | EEVGLLQLLG | 
    550:
    DPLPEKISQI | DDPHVGPAYI | FGPDSNSGQV | AQYHFPKLFF | RDFSLLFHVR | 
    600:
    PATEAAGVLF | AITDAAQVVV | SLGVKLSEVR | DGQQNISLLY | TEPGASQTQT | 
    650:
    GASFRLPAFV | GQWTHFALSV | DGGSVALYVD | CEEFQRVPFA | RASQGLELER | 
    700:
    GAGLFVGQAG | TADPDKFQGM | ISELKVRKTP | RVSPVHCLDE | EDDDEDRASG | 
    750:
    DFGSGFEESS | KSHKEDTSLL | PGLPQPPPVT | SPPLAGGSTT | EDPRTEETEE | 
    800:
    DAAVDSIGAE | TLPGTGSSGA | WDEAIQNPGR | GLIKGGMKGQ | KGEPGAQGPP | 
    850:
    GPAGPQGPAG | PVVQSPNSQP | VPGAQGPPGP | QGPPGKDGTP | GRDGEPGDPG | 
    900:
    EDGRPGDTGP | QGFPGTPGDV | GPKGEKGDPG | IGPRGPPGPP | GPPGPSFRQD | 
    950:
    KLTFIDMEGS | GFSGDIESLR | GPRGFPGPPG | PPGVPGLPGE | PGRFGINGSY | 
    1000:
    APGPAGLPGV | PGKEGPPGFP | GPPGPPGPPG | KEGPPGVAGQ | KGSVGDVGIP | 
    1050:
    GPKGSKGDLG | PIGMPGKSGL | AGSPGPVGPP | GPPGPPGPPG | PGFAAGFDDM | 
    1100:
    EGSGIPLWTT | ARSSDGLQGP | PGSPGLKGDP | GVAGLPGAKG | EVGADGAQGI | 
    1150:
    PGPPGREGAA | GSPGPKGEKG | MPGEKGNPGK | DGVGRPGLPG | PPGPPGPVIY | 
    1200:
    VSSEDKAIVS | TPGPEGKPGY | AGFPGPAGPK | GDLGSKGEQG | LPGPKGEKGE | 
    1250:
    PGTIFSPDGR | ALGHPQKGAK | GEPGFRGPPG | PYGRPGHKGE | IGFPGRPGRP | 
    1300:
    GTNGLKGEKG | EPGDASLGFS | MRGLPGPPGP | PGPPGPPGMP | IYDSNAFVES | 
    1350:
    GRPGLPGQQG | VQGPSGPKGD | KGEVGPPGPP | GQFPIDLFHL | EAEMKGDKGD | 
    1400:
    RGDAGQKGER | GEPGAPGGGF | FSSSVPGPPG | PPGYPGIPGP | KGESIRGPPG | 
    1450:
    PPGPQGPPGI | GYEGRQGPPG | PPGPPGPPSF | PGPHRQTVSV | PGPPGPPGPP | 
    1500:
    GPPGAMGASA | GQVRIWATYQ | TMLDKIREVP | EGWLIFVAER | EELYVRVRNG | 
    1550:
    FRKVLLEART | ALPRGTGNEV | AALQPPLVQL | HEGSPYTRRE | YSYSTARPWR | 
    1600:
    ADDILANPPR | LPDRQPYPGV | PHHHSSYVHL | PPARPTLSLA | HTHQDFQPVL | 
    1650:
    HLVALNTPLS | GGMRGIRGAD | FQCFQQARAV | GLSGTFRAFL | SSRLQDLYSI | 
    1700:
    VRRADRGSVP | IVNLKDEVLS | PSWDSLFSGS | QGQLQPGARI | FSFDGRDVLR | 
    1750:
    HPAWPQKSVW | HGSDPSGRRL | MESYCETWRT | ETTGATGQAS | SLLSGRLLEQ | 
    1774:
    KAASCHNSYI | VLCIENSFMT | SFSK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    E1823h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    E1823m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    U1823h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    U1823m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    P1823Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Collagen alpha-1(XVIII) chain
    Cat.:
    P1823Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Collagen alpha-1(XVIII) chain
    Monoclonal Antibody for Mouse Collagen alpha-1(XVIII) chain
    Protein for Mouse Collagen alpha-1(XVIII) chain
    Protein for Mouse Collagen alpha-1(XVIII) chain

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Primary structure of the alpha 1 chain of mouse type XVIII collagen, partial structure of the corresponding gene, and comparison of the alpha 1(XVIII) chain with its homologue, the alpha 1(XV) collagen chain."
      Rehn M.V. , Hintikka E. , Pihlajaniemi T.
      J. Biol. Chem.269:13929-13935(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3)
      strain: BALB/c.
      tissue: Liver.
    2. 2.
      "Characterization of the mouse gene for the alpha-1 chain of type XVIII collagen (COL18A1) reveals that the three variant N-terminal polypeptide forms are transcribed from two widely separated promoters."
      Rehn M. , Hintikka E. , Pihlajaniemi T.
      Genomics32:436-446(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Embryo.
    5. 5.
      "Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen."
      Rehn M.V. , Pihlajaniemi T.
      Proc. Natl. Acad. Sci. U.S.A.91:4234-4238(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1387 (ISOFORM 3)
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1347 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1615-1774
      strain: C57BL/6J.
      tissue: Head.
    7. 7.
      "Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins."
      Rehn M. , Pihlajaniemi T.
      J. Biol. Chem.270:4705-4711(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-562 (ISOFORMS 1 AND 3);TISSUE SPECIFICITY
    8. 8.
      "Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins."
      Oh S.P. , Kamagata Y. , Muragaki Y. , Timmons S. , Ooshima A. , Olsen B.R.
      Proc. Natl. Acad. Sci. U.S.A.91:4229-4233(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-1774
      tissue: Liver.
    9. 9.
      "Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region."
      Abe N. , Muragaki Y. , Yoshioka H. , Inoue H. , Ninomiya Y.
      Biochem. Biophys. Res. Commun.196:576-582(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 635-1774
      tissue: Embryo.
    10. 10.
      "Anticancer treatment of endostatin gene therapy by targeting tumor neovasculature in C57/BL mice."
      Jia S. , Zhu F. , Li H. , He F. , Xiu R.-J.
      Clin. Hemorheol. Microcirc.23:251-257(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1591-1774
    11. 11.
      "Endostatin: an endogenous inhibitor of angiogenesis and tumor growth."
      O'Reilly M.S. , Boehm T. , Shing Y. , Fukai N. , Vasios G. , Lane W.S. , Flynn E. , Birkhead J.R. , Olsen B.R. , Folkman J.
      Cell88:277-285(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF ENDOSTATIN;PROTEIN SEQUENCE OF 1591-1610
    12. 12.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-585
    13. 13.
      "Crystal structure of the angiogenesis inhibitor endostatin at 1.5-A resolution."
      Hohenester E. , Sasaki T. , Olsen B.R. , Timpl R.
      EMBO J.17:1656-1664(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF ENDOSTATIN
    14. 14.
      "Variable zinc coordination in endostatin."
      Hohenester E. , Sasaki T. , Mann K. , Timpl R.
      J. Mol. Biol.297:1-6(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1589-1774;DISULFIDE BONDS;MUTAGENESIS OF HIS-1591; HIS-1593; ASP-1595 AND ASP-1666;ZINC-BINDING SITES
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